The use of tNGS in the diagnosis of Q fever: A case report and review of cases of liver injury.

This report describes a case of Q fever with predominantly liver injury presentation. We used targeted next generation sequencing (tNGS) and immunologic methods to identify a case of acute stage infection of Q fever with liver injury; prompt diagnosis and treatment significantly improved the patient's prognosis and life quality. Further, to predict the homology and genetic diversity, the patient's sample was partially sequenced for insertion sequence (IS)1111 gene. Additionally, we reviewed similar cases in the past five years, aiming to provide evidence-based evidence for subsequent accurate diagnosis and treatment.