International journal of pharmaceutics
Process optimization in pharmaceutical hot-melt extrusion: real-time volatile detection via SIFT-MS combined with multivariate analysis.
Aaron D Smith, Ecaterina Bordos, Michael Devlin, Colin Hastie, Mark J Perkins, Vaughan S Langford, Alastair J Florence, John Robertson
Published: 202610.1016/j.ijpharm.2026.126623
Abstract
Establishing robust processing windows for pharmaceutical polymers during hot-melt extrusion (HME) remains challenging, as conventional thermal analyses reveal little about early chemical change. Here, selected-ion-flow-tube-mass-spectrometry (SIFT-M…
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