International journal of pharmaceutics
Subcutaneous administration of an endocrine-mimetic platform allows for prolonged tumor uptake of a tumor targeting protein.
Patricia Álamo, Hèctor López-Laguna, Marianna T P Favaro, Alberto Gallardo, Lorena Alba-Castellon, Antonio Villaverde, Ramon Mangues, Esther Vázquez
Published: 202610.1016/j.ijpharm.2026.126585
Abstract
Endocrine-like dynamic protein depots can be fabricated in vitro through the coordination of divalent zinc ions (Zn2+) with solvent-exposed histidine residues on functional proteins, leading to their controlled aggregation. The resulting microparticl…
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