International journal of pharmaceutics
PLGA nanoparticle-integrated microneedles for controlled transdermal delivery of ADT-OH to ameliorate endothelial dysfunction in vitro.
Mandeep Kaur Marwah, Pavanjeeth Balakrishnan, Sarah Junaid, Shakil Ahmad, Hala Shokr, Manoj Upadhya, Lissette Sanchez-Aranguren
Published: 202510.1016/j.ijpharm.2025.126535
Abstract
Endothelial dysfunction, a central feature of vascular diseases such as diabetes and atherosclerosis, is associated with oxidative stress and inflammation. Hydrogen sulphide-donors such as ADT-OH provide vascular protection but suffer from rapid clea…
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