International journal of pharmaceuticsNanoparticlesMolecular Dynamics SimulationLipidsEthanolRNA
Molecular Drivers of Self-Assembly in RNA-Loaded lipid nanoparticles Revealed by Coarse-Grained simulations.
Vincenzo Massotti, Antonio Buffo, Roberto Pisano
Published: 202610.1016/j.ijpharm.2025.126449
Abstract
The development of lipid nanoparticles (LNPs) has revolutionised RNA-based biopharmaceuticals, enabling efficient delivery of mRNA for therapeutic applications. LNPs consist of an ionisable lipid, a neutral phospholipid, cholesterol, and a PEG-ylated…
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