International journal of pharmaceuticsAnimalsBrainMiceProteolysisDisks Large Homolog 4 Protein
Modifying the PSD-95 inhibitor NA-1 for brain delivery through proteolytic stabilization and conjugation to the potentially brain homing peptide BR1.
Hannah Grønbech Kolberg, Amalie Kjær Andresen, Maria Thaysen, Sara Marie Øie Solbak, Camilla Jensen, Birger Brodin, Bente Gammelgaard, Mie Kristensen
Published: 202610.1016/j.ijpharm.2025.126434
Abstract
Delivering peptide-based therapeutics to the brain through systemic administration is limited by poor blood-brain barrier permeation, rapid proteolytic degradation, and off-target accumulation. The peptide NA-1, targeting PSD-95 interactions, holds p…
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