International journal of pharmaceuticsAtazanavir SulfateDarunavirHumansCaco-2 CellsCrystallization
Coadministration of a crystalline drug compromises supersaturation and membrane transport of an amorphous drug.
Noor Alkalla, Amjad Alhalaweh, Christel A S Bergström, Na Li, Lynne S Taylor
Published: 202610.1016/j.ijpharm.2025.126388
Abstract
Treating complex medical conditions often requires the concurrent administration of multiple drugs, either taken simultaneously as separate dosage forms, or as a combination product. This study investigates the impact on the achievable supersaturatio…
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