International journal of pharmaceuticsPiroxicamSolubilityPolysorbatesExcipientsDrug Delivery Systems
Mechanistic investigation of polymorphic transformation and solubilization in piroxicam multicomponent delivery systems via experimental and multiscale simulation approaches.
Jialong Wang, Pu Zheng, Ke Zuo, Jianhong Zhang, Xinru Chen, Liu Yang, Jianwei Liu, Xiumei Ke, Qianqian Zhao
Published: 202510.1016/j.ijpharm.2025.126276
Abstract
The solid-state structure of poorly soluble drugs significantly influences their solubility and oral bioavailability. Here, multicomponent delivery systems of Piroxicam (PRX MC-DSs) have been developed by incorporating PVP, Tween, and Na2CO3. The mec…
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