International journal of pharmaceuticsDocetaxelLeuprolideHumansNanoparticlesDrug Liberation
Self-assembled leuprolide-oleic acid nanoparticles encapsulating docetaxel for synergistic drug delivery.
Jeongro Lee, Hy Dinh Nguyen, Sura Saad Abdullah, Raimar Löbenberg, Beom-Jin Lee
Published: 202510.1016/j.ijpharm.2025.126235
Abstract
In the present study, an amphiphilic leuprolide acetate (LEU)-oleic acid (OA) conjugate (LOC) was synthesized by conjugating the peptide drug LEU with OA to form self-assembled nanoparticles (LON). This may maximize the synergistic effectiveness of f…
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