International journal of biological macromolecules
Structural insights into substrate binding, domain swapping and heat resistance of a hyperthermostable archaeal AIR synthetase.
Yu-Hung Chen, Yen-Chieh Huang, R Guru Raj Rao, Hao-Chin Chang, Yu-Hsuan Lan, Atsushi Nakagawa, Jeyakanthan Jeyaraman, Chun-Jung Chen
Published: 202610.1016/j.ijbiomac.2026.150493
Abstract
The enzyme 5-aminoimidazole ribonucleotide synthetase (AIR synthetase, AIRS, known also as PurM) catalyzes the fifth step in the de novo purine biosynthetic pathway: the ATP-dependent conversion of formylglycinamidine ribonucleotide (FGAM) to aminoim…
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