International journal of biological macromoleculesCheeseAspartic Acid ProteasesAmino Acid SequenceCaseinsMolecular Docking Simulation
In silico design of a chimeric aspartic protease for cheese production using parental sequences from 2ASI and 1MPP.
Shilan S Saleem, Mohd Basyaruddin Abdul Rahman, Adam Thean Chor Leow, Noor Dina Muhd Noor, Abu Bakar Salleh, Siti Nurbaya Oslan
Published: 202610.1016/j.ijbiomac.2026.150240
Abstract
Aspartic proteases from Rhizomucor miehei (RMP; PDB 2ASI) and Mucor pusillus (MPP; PDB 1MPP) are widely used in cheese production for milk coagulation, but their high thermostability and nonspecific proteolytic activity can cause over-hydrolysis of c…
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