International journal of biological macromoleculesHumansalpha-SynucleinAutophagyProteasome Endopeptidase ComplexCell Line
Differential roles of proteasome and autophagy in α-synuclein and E46K oligomer clearance: insight into the modulatory effects of the dopamine metabolite DOPAC.
Manuela Leri, Philipp Trolese, Ilenia Inciardi, Patrizia Polverino de Laureto, Monica Bucciantini
Published: 202610.1016/j.ijbiomac.2026.150224
Abstract
The build-up of misfolded α-synuclein (Syn) proteins plays a key role in diseases such as Parkinson's disease. Here, we compared the cytotoxicity and intracellular processing of wild-type and E46K mutant Syn aggregates in SH-SY5Y neuroblastoma cells…
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