International journal of biological macromoleculesPhosphate-Binding ProteinsPyroptosisHumansHigh-Throughput Screening AssaysIntracellular Signaling Peptides and Proteins
A high-throughput reporter assay for screening potential gasdermin D inhibitors from natural products.
Xiaolu Liu, Jiating Fu, Ruohong Yang, Haoyan Zhou, Ping Li, Jun Chen
Published: 202610.1016/j.ijbiomac.2026.150110
Abstract
Pyroptosis, an inflammatory programmed cell death, is typically initiated by inflammasomes and executed by gasdermin proteins. Gasdermin D (GSDMD)-mediated pyroptotic cell death and downstream inflammation cascades are crucial innate immune mechanism…
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