International journal of biological macromolecules
A novel Amycolatopsis sulphurea L-alanine dehydrogenase with enhanced bidirectional catalysis: Rational design, expression, and biochemical characterization.
Tuba Okur Aksu, Onur Serçinoğlu, Fatih Aktaş, Barış Binay
Published: 202610.1016/j.ijbiomac.2026.150108
Abstract
The enzyme L-alanine Dehydrogenase (L-AlaDH) catalyzes the reversible conversion of pyruvate to L-alanine, utilizing NAD(H) and NAD+ as cofactors. Specifically, reductive amination facilitates the conversion of pyruvate to L-alanine in the presence o…
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