International journal of biological macromolecules
Modular pentameric protein scaffold based on glutaraldehyde-crosslinked Stx1B for superior multivalent therapeutics.
Ronglian Xu, Yating Zhu, Ling Zhang, Qi Chen, Haofei Hong, Zhifang Zhou, Zhimeng Wu, Roland J Pieters, Jie Shi
Published: 202510.1016/j.ijbiomac.2025.150024
Abstract
Multivalent therapeutics harness nature's design principles to achieve enhanced binding avidity, facilitate receptor clustering-mediated signaling modulation, and enable coordinated multi-epitope targeting. These combined properties make them particu…
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