International journal of biological macromolecules
Neutralizing nanobodies against SARS-CoV-2 recognizing highly conserved epitopes at the Spike's S2 subunit.
Daniel Polo-Megías, Mario Cano-Muñoz, Philipp Trolese, Sara Lestani, Ilaria La Rocchia, Andrea Pierangelini, Benedetta Fongaro, Patrizia Polverino de Laureto, Francisco J Morales-Yánez, Jonathan Vaneyck, Alain Vanderplasschen, Thomas Decoville, Géraldine Laumond, M Carmen Salinas-Garcia, Ana Cámara-Artigas
Published: 202610.1016/j.ijbiomac.2025.150022
Abstract
The formation of a six-helix bundle between the conserved heptad-repeat regions 1 and 2 (HR1 and HR2) in SARS-CoV-2 Spike's S2 subunit is essential for membrane fusion and represents a promising therapeutic target. Previously, we reported recombinant…
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