International journal of biological macromolecules
Immobilization of l-asparaginase on oxidized bacterial cellulose to enhance stability and cytotoxic activity.
Anastasiya N Shishparenok, Yulia A Gladilina, Marina V Pokrovskaya, Svetlana S Aleksandrova, Sergey V Kraevsky, Yuri D Ivanov, Andrey F Kozlov, Igor D Zlotnikov, Elena V Kudryashova, Denis L Atroshenko, Dmitry D Zhdanov
Published: 202510.1016/j.ijbiomac.2025.149992
Abstract
l-asparaginase (l-ASNase) is a key therapeutic enzyme used to treat acute lymphoblastic leukemia (ALL). However, its use against solid tumors cells is limited due to its instability, rapid inactivation, and resistance mechanisms; thus, developing nov…
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