International journal of biological macromolecules
Mechanism of 1,6-hexanediol-induced protein droplet dissolution: Thermodynamic insights from amino acid solubility.
Haruna Oda, Tomoto Ura, Hideaki Ono, Shinji Tanaka, Tomoshi Kameda, Momoyo Wada, Kentaro Shiraki, Atsushi Hirano
Published: 202510.1016/j.ijbiomac.2025.149841
Abstract
Protein solutions can form droplets through liquid-liquid phase separation, a phenomenon involved in various intracellular processes. The aliphatic alcohol, 1,6-hexanediol (1,6-HD), known for its ability to dissolve protein droplets, is commonly used…
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