International journal of biological macromoleculesHumansCarcinomaNon-Small-Cell LungLung NeoplasmsPhosphorylation
Mitogen-activated protein kinase 10 suppresses non-small cell lung cancer metastasis through phosphorylation-dependent ubiquitination of keratin 16.
Juncong Luo, Nini Li, Huanwen Zeng, Weiyu Zhang, Xiaoli Liu, Zhanyu Li, Zizi Li, Leru Kuang, Hongyu Zhang, Fujie Jia, Xiaofeng Pei
Published: 202610.1016/j.ijbiomac.2025.149740
Abstract
Keratin 16 (KRT16), an intermediate filament protein frequently overexpressed in metastatic cancers, is primarily regulated at the transcriptional level. In this study, we identified mitogen-activated protein kinase 10 (MAPK10) as a pivotal kinase th…
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