Development of selumetinib-loaded solid dispersion based on low molecular weight methylcellulose for the enhanced solubility, stability, dissolution, and bioavailability.

The poor water solubility and bioavailability of selumetinib sulfate (SEL) limit its clinical potential as a promising anticancer drug. The aim of this study was to develop a solid dispersion (SD) of SEL as a new formulation strategy. Methylcellulose…

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