International journal of biological macromoleculesHumansrab GTP-Binding ProteinsEndocytosisProtein TransportGTPase-Activating Proteins
Molecular basis of Rab43 inactivation by RN-Tre in endocytic trafficking unveils a general Rab-GAP recognition mechanism.
Jun Wang, Tonghai Liu, Zhengwei Zhang, Wupeng Yan
Published: 202610.1016/j.ijbiomac.2025.149561
Abstract
TBC domain-containing Rab GTPase-activating proteins (TBCs) play key roles in regulating intracellular trafficking, and mutations in these proteins can disrupt Rab inactivation and contribute to human disease. However, the molecular principles govern…
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