International journal of biological macromoleculesAnimalsPodocytesAutophagyDiabetic NephropathiesPolysaccharides
METTL3-mediated m6A modification of SIRT1 mRNA modulates podocyte autophagy in diabetes nephropathy with the treatment effect of Astragalus polysaccharide.
Mingfei Guo, Yaji Dai, Xingxing Zhuang, Wulin Yang, Jun Chang
Published: 202610.1016/j.ijbiomac.2025.149473
Abstract
Diabetic nephropathy (DN) is characterized by proteinuria, glomerular dysfunction, and renal injury, with podocyte autophagy dysregulation playing a pivotal role in DN progression. Our previous studies identified N6-methyladenosine (m6A) modification…
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