International journal of biological macromoleculesTriazolesSchiff BasesGlutathione ReductaseMolecular Dynamics SimulationEnzyme Inhibitors
Structure-guided discovery of submicromolar 1,2,4-triazole-Schiff-base inhibitors of glutathione reductase.
Sevda Manap, Hande Akar, Hilal Medetalibeyoğlu, Abdurrahman Atalay, Zehra Can, Yakup Kara, Muzaffer Alkan, Murat Beytur, Haydar Yüksek, Ahmet Buğra Ortaakarsu
Published: 202610.1016/j.ijbiomac.2025.149471
Abstract
Glutathione reductase (GR) plays a crucial role in maintaining cellular redox balance and is a promising target for ferroptosis-based cancer therapies. In this study, we report the design, synthesis, and comprehensive evaluation of a novel series of…
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