International journal of biological macromoleculesHumansMolecular Docking SimulationCell LineTumorBasic Helix-Loop-Helix Proteins
Evaluating the therapeutic role of salvianolic acid A on pancreatic cancer cells through interaction with the intrinsically disordered protein NUPR1.
María Gabriela Álvarez-Rodríguez, Matías Estaras, Felipe Hornos, Bruno Rizzuti, Patricia Santofimia-Castaño, Juan L Iovanna, José L Neira
Published: 202610.1016/j.ijbiomac.2025.149435
Abstract
The nuclear protein 1 (NUPR1) is an intrinsically disordered protein (IDP) involved in stress processes in the cell. We have been developing, by using organic chemistry, several small molecules which hamper in vitro and in cell-based assays NUPR1 bio…
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