International journal of biological macromoleculesImmunoglobulin GHydrogen-Ion ConcentrationAntibodiesMonoclonalBuffers
Effects of buffer type and pH on biophysical properties and stability of IgG4 monoclonal antibodies: Uncovering dynamic shifts in stability predictors.
Yan Gao, Hengqian Wu, Lili Wang, Heng Zhang, Zhuang Ding, Zhengping Wang, Lingfeng Gao, Erpeng Zhou, Jun Han
Published: 202610.1016/j.ijbiomac.2025.149425
Abstract
Rapid development of biopharmaceuticals requires reliable predictive tools to assess the stability of therapeutic proteins. This study presents a comprehensive biophysical characterization of an IgG4 monoclonal antibody formulated in three buffers, s…
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