International journal of biological macromoleculesAlcohol OxidoreductasesMetagenomeLakesMolecular Docking SimulationStereoisomerism
Stereoselective synthesis of (S)-3-Hydroxy-3-phenylpropionate with a novel carbonyl reductase identified from a soda lake metagenome.
Xin Xu, Xiaokun Hong, Weiqing Zeng, Renxiang Yan, Feng Li, Chun Meng, Xian''ai Shi, Jiewei Luo, Guozeng Wang
Published: 202610.1016/j.ijbiomac.2025.149193
Abstract
This study aimed to discover novel carbonyl reductases from a soda lake metagenome for the efficient synthesis of the chiral drug intermediate (S)-ethyl 3-hydroxy-3-phenylpropionate ((S)-EHPP). A carbonyl reductase (denoted as SLCR1) was identified a…
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