International journal of biological macromoleculesNanoparticle Drug Delivery SystemCoumaric AcidsBrain NeoplasmsSurface-Active AgentsHydrogen-Ion Concentration
Supramolecular complex of a gemini amphiphilic pseudopeptide and p-coumaric acid as a pH- responsive drug delivery system for brain cancer therapy.
Ahmed H Lotfallah, Jose J Andreu, Rania M Hathout, Dina H Kassem, Shaimaa S Ibrahim, Ahmad Abdelwaly, Khaled M Darwish, Belen Altava, Eduardo García-Verdugo, Santiago V Luis
Published: 202510.1016/j.ijbiomac.2025.149115
Abstract
Supramolecular complex based on Gemini amphiphilic pseudopeptides (GAP 5a) and para coumaric acid (p-CA) was designed, synthesized and formulated into nanovesicles as drug delivery system for brain cancer therapy. Molecular docking and molecular dyna…
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