International journal of biological macromoleculesAlzheimer DiseaseAnimalsets-Domain Protein Elk-1Presenilin-1Amyloid beta-Peptides
Targeting the PS1-ELK1 protein-protein interaction with a peptide-based inhibitor reduces Aβ production and alleviates memory decline in Alzheimer's disease.
Lilin Yi, Qiuyun Tian, Boqing Xu, Yayan Pang, Zhifang Dong
Published: 202510.1016/j.ijbiomac.2025.149074
Abstract
Alzheimer's disease (AD) is a common neurodegenerative disorder among the elderly. Our recent research revealed that increased ELK1 (E-twenty-six (ETS)-like protein 1) in AD competitively binds to the C-terminal fragment of presenilin-1 (PS1-CTF), th…
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