International journal of biological macromoleculesHumansProtein BindingDrug DiscoveryAnimalsProteins
Molecular glues: A new path to the world of the unattainable.
Maisam Khaledian, Hamid Sheikh, Fatemeh Babaei, Adeleh Divsalar, Mahdieh Gharshasbi, Christian Ottmann, Thomas Haertlé, Ali Akbar Saboury, Milad Rasouli
Published: 202510.1016/j.ijbiomac.2025.148861
Abstract
Molecular glues (MGs) are a new class of small molecules that can modulate protein-protein interactions, leading to selective protein degradation, stabilization or activation. This breakthrough opens new possibilities for treating diseases such as ca…
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