International journal of biological macromoleculesHumansCysteineSodium-Coupled Vitamin C TransportersHEK293 CellsProtein Domains
Cysteine residues located within the core domain of human vitamin C transporter, hSVCT2, are essential for its structural and functional properties.
Marcell Gatica, Carlos Aylwin, Karen Sweet, Alejandra Muñoz, Alejandro M Reyes, Carlos F Burgos, Juan Carlos Vera, Carola Muñoz-Montesino, Coralia I Rivas
Published: 202510.1016/j.ijbiomac.2025.148772
Abstract
SVCT2 is the most ubiquitous Vitamin C (Ascorbic Acid, AA) transporter, essential in cell function and disease, but its structural and transport mechanistic details remain unclear. Using the 3D structures of related transporters, including UapA and m…
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