International journal of biological macromoleculesPancreatic NeoplasmsHumansSmad4 ProteinAnimalsDisease Progression
DTL promotes pancreatic cancer progression through ubiquitin-mediated degradation of SMAD4.
Xi-Zhuang Pan, Ke Tang, Li-Kun Ren, Shao-Jie Chen, Song Chen, Si-Yuan Li, Ren-Jie Ni, Chang-Hao Zhu, Xing Wang, Yao-Zhen Pan
Published: 202510.1016/j.ijbiomac.2025.148692
Abstract
Pancreatic cancer, known for its aggressive progression and unfavorable prognosis, necessitates the urgent discovery of novel therapeutic targets. This study identifies DTL as an oncogenic driver by employing transcriptome sequencing of clinical spec…
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