International journal of biological macromoleculesHumansColorectal NeoplasmsRNALong NoncodingAnimals
HSF1 promotes malignant phenotype in colorectal cancer via super-enhancer-driven lncRNA EXOSC10-AS1 and targeting HSF1 confers sensitivity to poly (ADP-ribose) polymerase inhibitor Niraparib.
Ping Song, Xinling Liu, Qi Shen, Yanan Yu, Songyue Guo, Jiao Ren, Lu Zhang, Luoyu Zhu, Jinglei Zhang, Yanli Sun, Jiaqiu Li
Published: 202510.1016/j.ijbiomac.2025.148656
Abstract
Super-enhancers exert a versatile role in tumor development by recruiting distinct transcription factors. This research aimed to further reveal the relevance between super-enhancers and transcription factor HSF1, the underlying regulatory mechanisms…
Preview only. Read the full abstract at the source