International journal of biological macromoleculesLegionella pneumophilaMitochondriaHumansBacterial ProteinsPhosphoric Monoester Hydrolases
A Legionella pneumophila T4SS effector protein (Ravl) triggers mitochondrial fragmentation through phosphoinositide phosphatase activity.
Ruiling Zhang, Meiling Zhang, Xiaoyu Li, Zhifang Lu, Chen Song, Yangchun Du, Chelsy Chesterman, Laura van Staalduinen, Youjun Wang, Hairun Pei, Zongchao Jia, Jimin Zheng
Published: 202510.1016/j.ijbiomac.2025.148613
Abstract
Upon ingestion by macrophages, Legionella pneumophila hijacks host membrane trafficking by decorating Legionella-containing vacuoles (LCV), thereby escaping lysosomal degradation. L. pneumophila is dependent on the T4SS effector proteins to recruit m…
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