International journal of biological macromoleculesSuperoxide Dismutase-1SaccharomycetalesFermentationCodonHydrogen-Ion Concentration
Codon-optimized production of Cu/Zn superoxide dismutase (SOD1) in Komagataella phaffii: Functional characterization and high-yield fermentation strategy.
Abdulqader Al-Adeeb, Sahibzada Muhammad Aqeel, Qiuya Gu, Qiuhuan Ren, Wen-Long Liu, Amer Ali Mahdi, Xiaobin Yu
Published: 202510.1016/j.ijbiomac.2025.148583
Abstract
Cu/Zn superoxide dismutase (SOD1) is a vital enzyme that catalyzes the dismutation of superoxide radicals into oxygen and hydrogen peroxide. The large-scale production of recombinant eukaryotic SOD1 remains limited by challenges in achieving high yie…
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