International journal of biological macromoleculesCisplatinGastrointestinal MicrobiomeAnimalsColorectal NeoplasmsMice
Lactobacillus-derived exopolysaccharide enhances localized cisplatin chemotherapy by modulating gut microbiota in colorectal cancer.
Min Chen, Fanting Zhao, Xinhang Wang, Hua Zhang, Rui Yang, Yingjie Liu, Zhenzhen Si, Hong Fang, Zeying Cheng, Lichen Zhao, Chenranle Wang, Xiaoxiao Liu, Hongmei Zhu, Peng Chen
Published: 202510.1016/j.ijbiomac.2025.148581
Abstract
Colorectal cancer (CRC) remains a major cause of cancer-related mortality worldwide, while cisplatin-based chemotherapy is limited by systemic toxicity, poor tumor selectivity, and gut microbiota disruption. This study aimed to evaluate the therapeut…
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