International journal of biological macromoleculesCapsid ProteinsMolecular Dynamics SimulationDependovirusMutationProtein Binding
Understanding the host cell surface receptor recognition by adeno associated virus 2 capsid protein and its modulation through allostery-driven mutations: An integrative modelling and simulation approach.
Roumi Naskar, Prasun Pal, Kishore V L Parsa, Bobby Paul, Srinivas Oruganti, Sandipan Chakraborty
Published: 202510.1016/j.ijbiomac.2025.148553
Abstract
AAV (Adeno Associated Virus) vectors have emerged as a promising approach for efficient gene delivery in vivo, and AAV capsid engineering is required to achieve transduction efficiency and bypass pre-existing immunity. However, a lack of knowledge of…
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