International journal of biological macromoleculesNeutrophilsHumansAcute Kidney InjurySingle-Cell AnalysisTranscriptome
Integration of single-cell RNA sequencing and spatial transcriptomics reveals neutrophil diversity and spatial heterogeneity in acute kidney injury.
Xintong Liu, Zehua Li, Lichao Mao, Yao Lu, Linjia Cheng, Xiaohong Xin, Lei Jiang, Zuoyuan Wang, Pingping Sun, Lingyi Xu, Xizi Zheng, Chengang Xiang, Ying Chen, Suxia Wang, Gang Liu
Published: 202510.1016/j.ijbiomac.2025.148478
Abstract
Acute kidney injury (AKI) is a critical clinical condition, with limited effective pharmacological treatments. Neutrophil-mediated inflammatory cascades play a pivotal role in AKI pathogenesis. However, the neutrophil diversity in AKI remains inadequ…
Preview only. Read the full abstract at the source