International journal of biological macromoleculesChitosanHyaluronic AcidGelatinCarrageenanDrug Liberation
Chitosan-gelatin core patches with drug release-controlling hyaluronan or carrageenan barriers for oromucosal delivery of clobetasol propionate.
Natallia V Dubashynskaya, Valentina A Petrova, Marharyta Bialiauskaya, Zlata Livanovich, Katsiaryna Khainskaya, Iosif V Gofman, Igor V Kudryavtsev, Andrey S Trulioff, Artem A Rubinstein, Kseniya Hileuskaya, Yury A Skorik
Published: 202510.1016/j.ijbiomac.2025.148447
Abstract
Multilayered patches for oromucosal delivery of clobetasol propionate (CP) were developed to enhance localized efficacy and minimize systemic exposure. A structured polydimethylsiloxane backing was modified with gelatin, enabling subsequent polysacch…
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