International journal of biological macromoleculesAnimalsPPAR gammaTOR Serine-Threonine KinasesProto-Oncogene Proteins c-aktMitophagy
Peroxisome proliferator-activated receptor gamma (PPARγ) promotes the morula-to-blastocyst transition in Tibetan sheep embryos by enhancing mitophagy through suppression of the AKT/mTOR pathway.
Tianhao Li, Yangyang Pan, Tian Zhao, Xuefeng Bai, Donglan Zhong, Yuejiao Liao, Qiyong Zuo, Xin Liu, Sijiu Yu, Yan Cui
Published: 202510.1016/j.ijbiomac.2025.148371
Abstract
The morula-to-blastocyst transition (MBT) is a critical stage for successful embryo implantation, yet it represents the main developmental block during in vitro culture. In this study, transcriptomic and proteomic analyses were used to investigate th…
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