International journal of biological macromoleculesHIV-1Phytic AcidProtein BindingAnti-HIV AgentsHumans
Hexakisphosphate (IP6) potentiates HIV-1 maturation inhibitor binding at the CA-SP1 junction: insights from molecular modeling and biophysical assays.
Zixuan Zhao, Yinghong Ma, Ji Zhang, Yong Xie, Bing Li, Xiaoming Yang, Xiaohong Zhao, Zhonghao Sun, Haiyue Hu, Zhaocui Sun, Xudong Xu, Chinho Chen, Guoxu Ma, Haifeng Wu, Jing Xue
Published: 202510.1016/j.ijbiomac.2025.148302
Abstract
Bevirimat (BVM) and related compounds act as HIV maturation inhibitors (MIs), impeding protease-mediated cleavage of the Gag polyprotein by binding to and stabilizing the capsid (CA) and spacer peptide 1 (SP1) domains (CA-SP1). The CA-SP1 six-helix b…
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