International journal of biological macromoleculesPorcine epidemic diarrhea virusAnimalsVirus ReplicationHSP70 Heat-Shock ProteinsSwine
Heat shock protein HSPA1A promotes porcine epidemic diarrhea virus replication by targeting the viral RNA-dependent RNA polymerase.
Haolun Tian, Pengcheng Hao, Haiying Dong, Binyu Wu, Haixin Liu, Huimin Du, Kun Wang, Qian Du, Shuan Jia, Ming Zhang, Airideng Caicike, Yongpan Zhao, Guangming Zhao, Dewen Tong, Yong Huang
Published: 202510.1016/j.ijbiomac.2025.148267
Abstract
Porcine epidemic diarrhea virus (PEDV) is a highly pathogenic virus causing severe diarrhea in piglets. Upon infecting the host cells, PEDV assembles a viral core replication-transcription complex (RTC) that drives viral genome synthesis. NSP12, a co…
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