International journal of biological macromoleculesFerroptosisHumansCoenzyme A LigasesGallbladder NeoplasmsUbiquitination
SPINT2 inhibits NEDD4L-mediated ACSL4 ubiquitination to promote ferroptosis and suppress gallbladder cancer progression.
Peng Ye, Xiaolong Yang, Haodong Wang, Yifan Ren, Ming Gao, Yan Wang, Yarong Guo, Yuqing Sun, Jun Xu
Published: 202510.1016/j.ijbiomac.2025.148141
Abstract
Gallbladder cancer (GBC) is a highly aggressive malignancy characterized by poor prognosis and limited therapeutic options, largely due to late-stage diagnosis and a lack of defined molecular targets. This is the first study to elucidate the molecula…
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