International journal of biological macromoleculesReceptorsInterleukin-17HumansSignal TransductionMolecular Docking Simulation
Multiscale computational elucidation of Interleukin-17 receptor A-E3 ubiquitin ligase TRAF3IP2 signaling nexus: structural dynamics and hotspots for targeted autoimmune and anti-inflammatory therapeutics.
Rajath Ramachandran, Abdul Manan, Eunha Kim, Sangdun Choi
Published: 202510.1016/j.ijbiomac.2025.148092
Abstract
Autoimmune and inflammatory diseases represent a growing global health burden, with the IL-17 signaling pathway emerging as a prime therapeutic target. The protein-protein interaction between IL-17 receptor A (IL-17RA) and its adaptor ACT1 is central…
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