International journal of biological macromoleculesAmyloid beta-PeptidesMolecular Dynamics SimulationProtein AggregatesHumansProtein Multimerization
Insights into the coaggregation mechanisms of amyloid-α and amyloid-β.
Zihan Xu, Xingke Yan, Pengxuan Xia, Yanyan Zhu, Yujie Chen, Cong Guo, Huiyu Li
Published: 202510.1016/j.ijbiomac.2025.148086
Abstract
The aggregation of amyloid-β protein (Aβ) into oligomers and amyloid fibrils is a critical event in the pathogenesis of Alzheimer's disease (AD). Notably, previous studies have suggested that cross-interactions between amyloid-α protein (Aα) and Aβ c…
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