International journal of biological macromoleculesHumansElongation Factor 2 KinaseNeoplasmsMolecular Targeted TherapySignal Transduction
Unravelling the oncogenic role of eukaryotic elongation factor 2 kinase: A revisited review from underlying mechanisms to targeted therapy.
Lingjuan Zhu, Minru Liao, Zhichao Fan, Yu Tang, Junning Wen, Qingbo Liu, Bo Liu
Published: 202510.1016/j.ijbiomac.2025.148014
Abstract
Eukaryotic elongation factor 2 kinase (eEF2K), encoded by the human eEF2K gene, belongs to the "α-kinase" family of atypical protein kinases and requires calcium ions and calmodulin (CaM) for its activity. It is overexpressed in various tumor tissues…
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