International journal of biological macromoleculesHumansNeoplasmsFerredoxinsCopperAnimals
The emerging role of ferredoxin 1 in cancer: Insights into cuproptosis and therapeutic innovation.
Annan Wu, Kai Tu, Guangfeng Xia
Published: 202510.1016/j.ijbiomac.2025.147996
Abstract
Ferredoxin 1 (FDX1), a key component of the mitochondrial electron transport chain, is crucial in the copper-mediated cell death pathway known as cuproptosis. Located at the q22.3 locus on chromosome 11, FDX1 acts as a reductase and is integral to ce…
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