International journal of antimicrobial agents
ATP-binding cassette transporters mediate and regulate metronidazole resistance in Clostridioides difficile.
Teng Xu, Ying Zhou, Qingqing Xu, Li Wang, Yu Zhou, Shi Wu, Haihui Huang
Published: 202610.1016/j.ijantimicag.2025.107709
Abstract
OBJECTIVE: Metronidazole (MTZ) resistance in Clostridioides difficile is associated with decreased efficacy of MTZ. We studied the MTZ-resistant C. difficile strain sh182IR (minimum inhibitory concentration [MIC] = 32 mg/L) to characterize the role o…
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