International journal of antimicrobial agents
Effect of ibuprofen on the pharmacokinetics of intravenous flucloxacillin in healthy adults.
Alison Boast, Amy Legg, James McCarthy, Jason A Roberts, Stephen Yc Tong, Stephen Duffull, Amanda Gwee
Published: 202510.1016/j.ijantimicag.2025.107684
Abstract
OBJECTIVE: Ibuprofen is frequently co-administered with antibiotics for its analgesic effect when treating infections. In vitro studies have shown that ibuprofen exhibits concentration-dependent inhibition of organic anion transporters (OAT) 1 and OA…
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