International journal of antimicrobial agentsMycobacterium abscessusHumansAnti-Bacterial AgentsMycobacterium InfectionsNontuberculous
NucS Thr74Ile confers mutator phenotype in a globally disseminated clinical Mycobacterium abscessus subsp. abscessus clone.
Juan Li, Junsheng Fan, Zhili Tan, Anqi Li, Siyuan He, Yani Lin, Bing Li, Haiqing Chu
Published: 202610.1016/j.ijantimicag.2025.107677
Abstract
OBJECTIVE: The emergence of mutations conferring resistance to first-line drugs, macrolides and amikacin, is a major cause of treatment failure in Mycobacterium abscessus complex (MABC) infections; however, mutator strains predisposed to developing d…
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