International journal of antimicrobial agentsHumansAntifungal AgentsPharmacovigilanceTriazolesRandomized Controlled Trials as Topic
Adverse effects of posaconazole on adrenal steroid biosynthesis: An integrative approach using FAERS-based pharmacovigilance and systematic review with meta-analysis of randomised controlled trials.
Yuki Nakano, Kazumasa Kotake, Yuki Asai, Masayuki Murata, Masanobu Uchiyama, Nobuyuki Shimono, Hirotsugu Hasuwa
Published: 202610.1016/j.ijantimicag.2025.107676
Abstract
OBJECTIVES: Posaconazole, a broad-spectrum azole antifungal agent, is used for prophylaxis and treatment of invasive fungal infections. However, it has been associated with pseudoaldosteronism-a syndrome involving hypertension, hypokalaemia, and QT p…
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